Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii

نویسندگان

چکیده

Inflammatory bowel diseases (IBD) constitute a growing concern in western countries. They coincide with gut microbiota dysbiosis, including loss of immunomodulatory bacteria. Accordingly, probiotic products containing selected bacterial strains mitigate IBD. Selected Propionibacterium freudenreichii display promising modulatory properties and prevent colitis animal models. Dairy matrices protect propionibacteria surface antigens during digestive transit. However, the functional role dairy matrix components such fermented remains unknown. In present workthis study, P. CIRM-BIA129, strain known for its anti-inflammatory properties, was used to ferment whole milk, skim milk or ultrafiltrate. The preventive potential tested DSS-induced mice colitis, comparison their unfermented counterparts. freudenreichii-fermented prevented colitis. fat product potentiated anti-colitis effects probiotic. This work opens new perspectives developing foods.

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ژورنال

عنوان ژورنال: Journal of Functional Foods

سال: 2023

ISSN: ['2214-9414', '1756-4646']

DOI: https://doi.org/10.1016/j.jff.2023.105614